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Drug sensitivity assay under 3D cell culture condition

For customer who wants to evaluate drug effect against cancer cell under 3D cell culture condition

We are able to conduct drug sensitivity assay using recommended cell lines or cell lines provided by customer. We can calculate IC50 of novel candidate drug, and evaluate the existing drug effect against established cell line in 3D system. We also can compare the drug responses between 2D and 3D system.

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Setting an adequate drug concentration range
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We make proliferation curve of the target cell line, and pretest for confirmation of useful concentration range
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Evaluation of growth inhibitory effect of the drug
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We evaluate growth inhibitory effect of the drug in useful concentration range by luminescence ATP assay, and calculate IC50
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Observation of spheroid morphological change
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We confirm drug effect against not only proliferation but also spheroid morphology.

Example Data

Drug sensitivity of BT474 to Paclitaxel

The drug was added into culture media one day after cell seeding. Then viability was confirmed after additional 4 days culture. BT474 spheroids resist Paclitaxel compared to 2D.

PRICE
US$ 55.00/well~

Example
Please download from here.