screening of EMT inhibitor
For customer who wants to explore candidate of anti cancer metastasis drug
We conduct EMT inhibitor screening with unique assay system. In this system, we use NCP for 3D cell culture, and Hypoxia Probe for quantifying spheroid morphology change that induced by EMT cytokine. This system is compatible with high-throughput screening using chemical library.
analysis of EMT marker gene expression
EMT inhibitor screening
Using our assay system, some candidates of EMT inhibitor, include TGF-β receptor inhibitor, were screened from 1330 chemical compounds.
Validation: evaluation of expression change of EMT marker genes by qRT-PCR
It is confirmed that these hit compounds have the EMT inhibitor activity by evaluating the expression alteration of EMT marker genes.
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