ADME/Tox prediction assay in 3D platform
ADME/Tox drug properties, absorption, distribution, metabolism, elimination and toxicity, are crucial to the final clinical success of a drug candidate. ADMT/Tox prediction is also important for reduction the cost of new drug discovery and development before preclinical test. Presently, evaluation of drug-induced liver injury is conducted in animal model. Meanwhile, it is desired to establish the in vitro assay using human liver cell for reducing species-species differences in metabolism exist.
However, the current in vitro assay using human cell under 2D cell culture is insufficient, because liver cells immediately lost their liver activity in monolayer.
ORGANOGENIX offers the assay for evaluation of drug-induced liver injury under 3D cell culture condition.